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Retrieved from JAMA Internal Medicine

Glutathione deficiency contributes to oxidative stress (inflammation), which plays a key role in aging and the pathogenesis of many diseases including (but not limited to)

In essence, while STING normally aids innate immunity, its overactivation in the brain can harm neuronal health and accelerate Alzheimers progression via sustained neuroinflammation and microglial dysfunction

All new plasmids generated in this work are available through Addgene: #236545-236551