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The study confirmed FOXO4-DRI was effective across senescent cells generated by different methods (irradiation, doxorubicin, and replication stress), and documented that pre-treatment with FOXO4-DRI attenuated the dedifferentiation of chondrocytes during in vitro expansion establishing it as a valuable tool for research into senescent cell biology in cartilage and musculoskeletal models
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Studies show that increasing folate-rich foods can lower homocysteine and inflammatory markers, especially in people with the C677T variant
Animals were housed into enriched environmental conditions in groups of 10 animals per polycarbonate cage in a colony room under a 12 h light/dark cycle (12:00 AM-12:00 PM) under controlled temperature (253C) and humidity
Supernatants showed significantly increased type I (IFN-/
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