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The speed of the development pipeline only adds to the challenge as GLP1 therapies are being used for approved indications beyond diabetes and obesity, including heart, liver and renal disease
L-2-hydroxyglutarate production arises from noncanonical enzyme function at acidic pH
The boxed warning applies equally to semaglutide and tirzepatide because both classes were tested in rodent thyroid models
Lifestyle interventions remain the foundation of long-term management for both diabetes and obesity
Initially, some users may experience fatigue, but this often improves as the body adjusts to the medication
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