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FIGURE 4 4.5 Inhibition of glucagon release Considered an anti-insulin hormone, 2022 marks the 100th anniversary of the discovery of glucagon, which is produced in islet cells through the processing of prohormone-converting enzyme 2 (Pcsk2) and acts through glucagon receptor (GCGR) (Hayashi, 2011)

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Meanwhile, to further enhance the convenience of wound therapy and achieve controlled drug release, hydrogel-based (e.g., hyaluronic acid, alginate, and gelatin) delivery systems for drugs or exosomes can be established, providing an integrated intervention-delivery solution for precise regulation of ferroptosis in diabetic wounds [49, 87, 89, 98, 108]