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As the field develops, direct measurement of circulating MOTS-c may become a useful biomarker for guiding dose adjustments, similar to how IGF-1 is used to monitor growth hormone or testosterone levels guide TRT dosing

Enzyme replacement therapy for hypophosphatasia has shown promising results in human clinical trials, reducing mortality in hypophosphatasia and improving chondromalacia, lung function and exercise milestones in these patients [44]

& Okawa, M

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