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Structure-guided spike design has also been used to identify artificial substitutions in the spike sequence that can increase the expression, solubility, and stability of spike (termed HexaPro) for use as a vaccine antigen [165, 166]

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Abortive infections were detected by the coordinated expansion of SARS-CoV-2-specific T cells as well as the upregulation of a biomarker of infectioni.e., the interferon-stimulated gene IFI27during the first pandemic wave of infections [62]