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2 Since not all individuals with prediabetes progress to T2DM, the use of this term in its strictest sense has been questioned, and some prefer to use the term intermediate hyperglycemia

Retatrutide is studied for its activity across GLP-1, GIP, and glucagon receptor pathways

The phase 2 trial found that starting at 2mg rather than 4mg significantly reduced nausea rates during escalation, validating the conservative titration approach

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Nausea (most common, ~2044% in clinical data), diarrhea, vomiting, and constipation usually mild and fading after 48 weeks