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In addition, at 5 years, significantly fewer GLP-1 drug users (13.5%) than nonusers (19.9%) had died, for a 31% lower mortality risk with GLP-1 drug use (aSHR = 0.69

Orforglipron also is more likely to increase heart rate (by about 4 beats per minute)

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Studies have observed effects on: fibroblasts keratinocytes endothelial cells These cell types play essential roles in tissue remodeling and vascular regeneration, further explaining the peptide's role in wound healing

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