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In a 26-week study, orforglipron demonstrated a significant dose-dependent effect on weight loss, with weight reduction ranging from 8.6% to 12.6% across various dosages, compared to only 2.0% in the placebo group

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Rapid weight loss may be associated with loss of lean muscle mass, and this warrants monitoring

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Subcutaneous B12 injections are given under the skin, typically in the abdomen or outer thigh

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