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Chronic Dosing Protocol: AOD9604 administered intraperitoneally at 250 g/kg/day hGH administered at 1 mg/kg/day Treatment duration: 1428 days depending on cohort Daily administration via intraperitoneal injection Acute Testing Protocol: Single AOD9604 dose: 2 mg/kg 3-AR agonist BRL37344: 250 g/kg (for comparison) Indirect calorimetry measurements performed Measured Outcomes: Body weight, food intake, white adipose tissue (WAT) and brown adipose tissue (BAT) weights, plasma glycerol levels (indicating lipolysis), and 3-AR mRNA expression in adipose tissue

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As of September 2023 it is on the FDA Category 2 list of bulk drug substances that may not be compounded, and a PCAC review is scheduled for July 2026 under the name Emideltide

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Most therapeutic compounds target a single pathway, but this peptide orchestrates a coordinated biological response through at least six distinct molecular routes