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MSM, an endogenous cellular metabolite that acts as sulphur donor in many transmethylation reactions, is also able to act as an antioxidant and free radical scavenger

Arch Pediatr Adolesc Med 161:35661, PMID: 17404132 Rezaei Z, Saadat I, Saadat M (2012) Association between three genetic polymorphisms of glutathione S -transferase Z1 (GSTZ1) and susceptibility to bipolar disorder

This can lead to competition for glutathione precursors since the muscular system also relies on glutathione for aerobic muscular contraction [8]

For others, they can become chronic and severely affect quality of life