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GLP-1 receptor agonists increase nitric oxide bioavailability, hence enhancing renal blood flow autoregulation and diminishing oxidative stress in glomerular capillaries (Yaribeygi et al

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The fact that GLP-1R agonists are sometimes introduced if the patient is intolerant to metformin or metformin is contraindicated, or when patients on metformin are not achieving their HbA1c goals [71] represents essential background information here

Journal of Endocrinology (2002) 4