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Despite initially promising results, SAR425899 has been discontinued after phase 2 trials showed treatment related gastrointestinal disorders (NCT03437720)

Moreover, selenium can stimulate the activity of various enzymes involved in nutrient assimilation, further enhancing the plants ability to absorb and utilize these essential elements 7

(Exenatide is FDA approved as monotherapy for the management of T2DM.) Explicitly stated in the guideline for patients requiring dual or triple therapy, the AACE/ACE preferentially recommends the addition of a GLP-1 receptor agonist or a DPP-4 inhibitor (sitagliptin, saxagliptin), citing their efficacy and safety profiles as preferred agents over TZDs or sulfonylureas (SUs)

Strain: C57BL/6J

Results were reportedly positive, but the published data is limited