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Behavioral measurements should primarily include the percentage of time spent in the open quadrant, the percentage of entries into the open quadrant, the number of times the animal peeks down from the edge of the platform while in the open or closed quadrant, and the number of stretch-attend postures from the closed quadrant to the open quadrant

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Initially, three patients in the loading dose group and seven in the no loading dose group had GDS scores 5, decreasing to two patients in each group by study end