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203 Platelet-rich plasma (PRP) intraarticular injection, commonly used for OA treatment, 204 has been proven to inhibit mitochondrial damage mediated by LPS through diminishing ROS production, inhibiting DRP1 expression, and upregulating MFN1 expression, eventually repairing mitochondrial function
This demethylation specifically occurs at the promoter region of phosphoinositide-dependent protein kinase-1 (PDPK1), increasing its transcription
Is glutathione safe
doi: 10.1186/s12951-016-0177-x, 124
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