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The week 24 peak and subsequent decline One of the most important patterns in the data is the temporal profile

Supporting Liver Health The liver is the primary site of glutathione production and detoxification

Reduce dose or frequency if: IGF-1 exceeds the age-adjusted upper limit of normal but the patient is asymptomatic Fasting glucose rises 10 to 25 mg/dL from baseline but remains below 126 mg/dL Mild peripheral edema or joint stiffness appears and does not resolve within 2 weeks Systolic blood pressure rises 5 to 10 mmHg from baseline Discontinue CJC-1295 if: Fasting glucose exceeds 126 mg/dL on two consecutive draws IGF-1 remains above the upper limit of normal despite dose reduction New-onset carpal tunnel syndrome does not resolve after 4 weeks at reduced dose Echocardiogram shows new or worsening left ventricular hypertrophy PSA rises more than 0.75 ng/mL (annualized rate) from baseline Discontinuation should be followed by repeat labs at 4 and 8 weeks to confirm normalization

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