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(2025) T2DM: 47.3% reinitiated GLP-1 therapy within 1 year of discontinuation 57.3% reinitiated within 2 years Without T2DM: 36.3% reinitiated within 1 year 46.4% reinitiated within 2 years Key Factors Linked to Reinitiation: Patients age 65 years Less likely to reinitiate Weight regain after discontinuation Higher likelihood of restarting therapy Moderate to severe GI side effects during initial treatment Lower likelihood of reinitiation Main Takeaway: Most patients who initiated GLP-1 therapy stopped within one year, with higher discontinuation rates among those without T2DM

The prior authorization systems, formulary management platforms, and electronic health record integrations that sit between a clinicians prescribing decision and a patient filling a prescription were not designed for a drug class of this complexity, this volume, or this clinical significance

Temperature excursions above 8C cause irreversible methionine oxidation that eliminates lipotropic function

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