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In further research, it was found that berberine achieved antioxidant effects by reducing the expression of pro-inflammatory factors, apoptotic factors and nuclear transcription factor B (NF-b), as well as up-regulating the expression of peroxlsome proliferator-activated receptor- coactlvator-1 (PGC-1) and manganese superoxide dismutase

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Studies have shown that inhibiting STAT3, using inhibitors like Stattic, can reduce the accumulation of M-MDSCs and improve the immune response [96]

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