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This is not a failure of willpower its biology
In TLE and cortical developmental malformations, translocation of HMGB1 impacts upregulation of TLR4 and RAGE (also activated by HMGB1) in neurons and astrocytes (196, 197)
Importantly, preclinical studies showed that weight reduction occurred particularly in abdominal adipose tissue, the visceral fat depot most strongly associated with metabolic health risks
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Buonsenso, D., Piazza, M., Boner, A
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