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Call the clinic between visits rather than waiting for your next appointment if nausea or vomiting is persistent enough to affect hydration, if constipation does not resolve with the measures above, if you are unable to keep food or fluids down, or if you develop severe or persistent abdominal pain

3- Enhanced Cardiovascular Health Orforglipron consistently improves lipid profiles and reduces systemic inflammation, significantly lowering overall cardiovascular risk

For most people, this is not clinically significant