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Retatrutide works like other weight loss and type 2 diabetes medications, but what makes it different is that it can target three receptors (triple agonist) at once: Gastric inhibitory polypeptide receptor (GIP) Glucagon-like peptide-1 receptor (GLP-1) Glucagon receptors (GCG) This unique triple-action may make it more effective than GLP-1 and GLP-1/GIP medications

Compounded semaglutide is a custom-made medication prepared by compounding pharmacies

Side-by-side comparison For a deeper dive into how these medications compare across all dimensions, including dosing, dosage charts , and transition protocols, see our comprehensive semaglutide versus tirzepatide comparison

Wegovy (semaglutide) cost without insurance A 28-day supply of Wegovy costs $1,349.02 per month, which is about $337.25 per week or $16,188.24 per year

Many clients find it convenient to take their injection in the evening, as it allows them to relax and not have to worry about it during their busy daytime hours