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14,15 It has also been noted that endogenous GHK declines with age, with higher levels in young healthy people as compared to older adults around age 60

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Protein phosphatases belong to two major families of phosphatases: serine/threonine protein phosphatases and protein tyrosine phosphatases (PTPs)

137,138 ERS Continuous insulin production and secretion in cells under chronic hyperglycemia and IR result in the overload of protein folding machinery and the accumulation of excessive misfolded or unfolded proteins in the ER, therefore triggering UPR and the ERS