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Going from tirzepatide to semaglutide often produces more noticeable fatigue because you are losing the GIP component that may have been contributing to energy levels

Instead, they require patience and a long-term approach to achieve meaningful results

There have also been instances of pharmacies using different salt forms of semaglutide, which have not been approved by the FDA and whose safety and efficacy are unknown. Manne-Goehler said that many reports have suggested that the current compounded GLP-1s have a higher number of severe side effects

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