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The reason many people struggle to lose weight with lifestyle changes alone is that the biology gets in the way, says San Diego internist and obesity specialist Eduardo Grunvald, MD

It's a legal workaround, not a medical one

Microdosing GLP-1 for Weight Loss and Beyond

Suppression of Glucagon Secretion These agents reduce glucagon secretion from pancreatic alpha cells, particularly during hyperglycemia, which helps decrease hepatic glucose output

Further, recent studies in flies showed that (1) short-sleeping mutants are extremely sensitive to oxidative stress, suggesting that a key function of sleep is to defend against oxidative stress (Hill et al