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While most of the cysteine for glutathione was derived from exogenous source in nutrient replete culture, serine-derived cysteine may become more important under nutrient-limiting conditions

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This is why the recommendation for T/T individuals is specifically active folate rather than folic acid folic acid accumulates as unmetabolized folic acid in the circulation of T/T individuals, potentially with pro-inflammatory consequences, rather than supplementing the genuinely deficient 5-MTHF pool