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PubMedPMC 64
Red flags requiring urgent assessment include rapidly progressive unilateral swelling (consider deep vein thrombosis or cancer recurrence), acute cellulitis with systemic features (requiring immediate antibiotic therapy), or new masses in the affected area
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Critically, an early vicious cycle emerges between MQC dysfunction and localized inflammationinflammatory cytokines suppress core MQC components, while MQC failure-generated ROS and mtDNA further exacerbate inflammation (10, 86)
degraded peptides often look identical to stable ones
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