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Safety considerations and side effects No responsible discussion of peptide safety glosses over side effects
The review confirmed GLP-1R is expressed at high levels on -cells, where GLP-1 stimulates somatostatin secretion which in turn indirectly suppresses both glucagon and insulin through paracrine mechanisms
While the clinical trials for semaglutide showed significant results, those results occurred over many months of consistent use at the correct dose
The lower the GFR, the greater the damage to the kidneys, associated with the accumulation of toxins in the body, which increases the risk for hypertension, atherosclerotic cardiovascular disease, and progression to ESKD and the need for kidney replacement therapies, such as dialysis and transplantation
If the safety and modest efficacy data from the published trials translate to our patient population, it would give us a tool that acts directly on fat cell metabolism rather than appetite, with a side effect profile that appears extremely well-tolerated
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