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Although no data from head-to-head trials comparing retatrutide to other currently approved obesity treatments exist, data from the phase 2 studies with retatrutide suggest that at higher doses, retatrutide could lead to greater WL compared to the most efficacious approved treatments for obesity and T2D such as tirzepatide 15 mg and semaglutide 2.4 mg (Fig
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Early podocyte injury, characterized by their effacement and detachment, compromises the filtration barrier integrity and contributes to albuminuria and subsequent glomerulosclerosis [1,19]
Post-translational modifications of the protein termini
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