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A new Gcg and GLP-1 co-agonist eliminates obesity in rodents

Steiger, M.G., Patzschke, A., Holz, C., et al., Impact of glutathione metabolism on zinc homeostasis in Saccharomyces cerevisiae, FEMS Yeast Res., 2017, vol

GLP-1 and GLP-2 are both gut hormones cut from the same precursor protein, proglucagon, and released together by intestinal L-cells after eating

Digestive discomfort is also a common side effect, but this can typically be avoided by eating smaller meals at more frequent intervals throughout the day

While they share similarities, Mounjaro and Ozempic have some key differences, including slightly different mechanisms of action, active ingredients, dosing, and effectiveness