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A 2022 wound healing study published in the Journal of Investigative Dermatology used 750mcg AHK-Cu administered subcutaneously every 48 hours for 14 days, demonstrating 43% faster re-epithelialization compared to saline controls

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Moreover, the authors suggested that the presence of AHK-Cu may have reduced the number of apoptotic dermal papilla cells

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AOD-9604 Research Protocols & Administration Dosing in Published Research Research investigations have employed diverse AOD-9604 doses across species and administration routes: Rodent studies: 250-500 mcg/kg orally or intraperitoneally was most common for obesity research Rabbit models: 0.25 mg per joint for osteoarthritis studies (intra-articular injection) Pig pharmacokinetic studies: 1.5 mg/kg IV and 2 mg/kg oral for metabolism characterization Human clinical trials: Oral doses of 0.25-10 mg daily