Pathological hypertrophy, in contrast, is commonly linked to hypertension, valvular disease, diabetes, obesity, cardiomyopathy, renal disease, or aging and may progress to fibrosis, capillary rarefaction, diastolic dysfunction, systolic failure, arrhythmia, and sudden death ( The adult heart has high ATP demand and normally oxidizes multiple substrates, especially fatty acids, glucose, lactate, ketone bodies, and amino acids
overtraining Emotional or psychological stress i.e
[4] Boosts Athletic Performance: Glutathione boosts muscle recovery after a heavy workout for uninterrupted training sessions
Given this information, emerging therapies which target GSH homeostasis such as N-acetylcysteine (NAC), GSH esters, or activation of antioxidant response elements may provide new avenues to interrupt oxidant-driven inflammation in these diseases
(August 2023)