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Patients with T2DM and a high cardiovascular risk might reduce their risk of atherosclerotic events via the use of GLP-1RA ( Many physicians and researchers have become interested in the potential cardiovascular advantages of GLP-1 and GLP-1-based medication since the discovery of GLP-1Rs on cardiomyocytes
Manik and Singh, 2022)
V., Horsham, C., & Janda, M
It is often avoided because of weight gain concerns, but the mechanism is more nuanced than that label suggests
The study of nearly 28,000 23AndMe users who reported taking the weight-loss drugs found that a mutation in GLP1R, the gene for the protein targeted by GLP-1 drugs, is modestly but significantly associated with increased efficacy of the medications, researchers reported in Nature
