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Cell 132 , 387396 (2008)

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Notes This article was published on June 23, 2023, at NEJM.org

As we age, the skins natural collagen and elastin fibres begin to weaken, leading to laxity, fine lines, and loss of firmness

The paratope of Fab 3F52 involves residues of all complementarity determining regions (CDRs) of both heavy and light chain variable regions (VH and VL), although the CDR3 loops appear to be responsible for the most critical interactions covering a major part of the hydrophobic interface

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