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Subgroup analyses (Figure 5) (exploratory) revealed similar directional trends across subgroups, including patients with organ transplantation (HR 0.27, 95% CI 0.090.82

Data from LEADER, SUSTAIN-6, PIONEER 6 and REWIND allowed further investigation of the association between GLP-1RA and eGFR-related endpoints

This may be done by discussing with patients the need to start basal insulin on a low dose and slowly build to a regular dose, which will help them avoid hypoglycemia

Administer an initial dose of 500 mg/m, dissolved in 100 ml of normal saline, via intravenous administration, followed by a maintenance dose of 300600 mg daily via intramuscular injection