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Further, researchers should note that due to their upregulation of GH and IGF-1, GH secretagogues in general may accelerate disease progression in subjects with malignancies

10.1016/j.clinthera.2015.04.002 Clin

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Intriguingly, the glutamine-dependent checkpoint at late G1 phase in the cell cycle is dysregulated in K-Ras-driven cancer cells 185

For this reason, several novel NBDHEX analogues, with improved selectivity for GSTP1-1, have been synthesized and characterized to obtain new therapeutic opportunities for the treatment of drug resistant tumors including human melanoma 100,101