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Topol noted that "there is no evidence from randomized trials in humans that any of these peptides provide the benefits that are advocated," and the same evidence gap applies in reverse to long-horizon harms

Heartburn or Acid Reflux: Slower gastric emptying can sometimes cause stomach acid to back up into the esophagus

Compounded drugs may be improperly stored (since injectable GLP-1 medications require refrigeration), and some may be fraudulent (missing high-quality active ingredients)

PubMed Friedman TC, Garcia-Rodriguez C, Sung C, et al

We're literally just trying to get to a place of negative energy balance, and the GLP-1 is essentially an assist for doing that