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Both in vivo and in vitro studies have shown that FAK silencing markedly reduces the upregulation of PGC-1, NRF-1, mitochondrial DNA (mtDNA), and left ventricular hypertrophy caused by pressure overload[152]

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The analysis also revealed with low certainty that GLP-1 receptor agonists may have little or no effect on colorectal, esophageal, liver, gallbladder, ovarian, or endometrial cancer, multiple myeloma, or meningioma