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Oxidative Stress and Amyotrophic Lateral Sclerosis Presence of OS biomarkers and high levels of ROS have been determined in the CNS regions specifically in ALS patients (Golenia et al., 2014), which indicates that impaired redox homeostasis is a relevant factor and associated with the development and progression of neurodegeneration in fALS and sALS (Petrov et al., 2017
Crucially, no existing studies have evaluated the effects of alternative LC dosing strategies, such as split-dose intake, in this population
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