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It is a glucagon-like peptide-1 (GLP-1) receptor agonist that mimics natural hormones made by your gut

There are eight GLP-1R/GIPR/GCGR agonists under development in the world, of which, Rita's Retatrutide has made the fastest progress and launched the third phase clinical trial in June this year

Glutamate is the most important transmitter for normal brain function, but excessive glutamate may cause toxic damage to the brain

| How these medications work | Head-to-head clinical evidence | Side effects and tolerability | Practical differences | Cost and access in the UK | Who might prefer each option

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