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Studies have shown that IF significantly enhances GH secretion and elevates insulin-like growth factor binding protein 1 (IGFBP1) levels up to fivefold [42], thereby modulating IGF-1 bioavailability and enhancing autophagy, lipolysis, and muscle preservation [42, 43]

Accordingly, the DPP-4 protein has been identified in both subcutaneous and visceral adipose tissue, with its expression, particularly in visceral adipocytes, being more pronounced in obese subjects (81)

PMID: 34209583