In fasted healthy normal weight patients, GLP-1 (7-36) amide injection reduced fMRI activity induced by food images, in all brain areas studied (amygdala, insula, caudate, NAc, orbitofrontal cortex, and putamen), compared to saline injection [43]
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Systemic side effects Nausea is the most commonly reported side effect of GLP-1 therapy, and it is a medication effect, not an injection technique issue