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Yes, exercise is encouraged but adjust intensity during initial weeks

That matters because glucagon activation increases your baseline calorie burn and enhances fat breakdown through heat production, basically adding a metabolic accelerator that semaglutide and tirzepatide lack entirely

If neurological symptoms are present, injections may be needed every two months

Therefore, researchers are actively investigating the potential of NNMT inhibitors such as 5-amino-1MQ in experimental models