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adults 70% of whom count as overweight or obese fully 12% are estimated to have used GLP-1s, and many lose 10% or more of their body weight when they do

[...] Even though the carboxylic acid valproate (VPA) is an HDACi with weak inhibitory potential, it is an interesting drug for clinical trials due to its well-characterized pharmacodynamic and pharmacokinetic profile (see Table 6)

Targeting nuclear receptors that regulate cellular metabolism has emerged as a promising therapeutic strategy for MASH