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Most gut peptide research has been conducted in rodent models, and while the mechanistic data is compelling, translation to human outcomes has not been established through large clinical trials

The FDA, recognizing this issue, has prioritized reviewing generic applications for drugs in short supply, as seen with its recent approval of exenatide (Byetta) by Amneal Pharmaceuticals and Tevas earlier launch of an authorized generic version of Victoza in the U.S

Despite these benefits, long-term LC administration has been associated to cardiovascular risks due its conversion to trimethylamine- N -oxide (TMAO) by the gut microbiota

doi: 10.3109/09513599209081006

The novel DA3-CH dual incretin restores endoplasmic reticulum stress and autophagy impairments to attenuate Alzheimer-Like pathology and cognitive decrements in the APPSWE/PS1DeltaE9 mouse model