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For musculoskeletal, tendon, ligament, or systemic targets, injection is the better-supported route because all relevant animal healing studies used injected BPC-157, and systemic absorption from capsules in humans is unverified

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Moreover, some histone modifying enzymes have an affinity for SAM that is in the physiological range of this metabolite and, therefore, their enzymatic output is sensitive to changes in SAM levels 42