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Pendulum itself states that meaningful microbiome changes require approximately 90 days
Limit use to 23 days
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Summary: In individuals with both overweight/obesity and type 2 diabetes, the STEP 2 trial reported a mean weight loss of -9.6% with semaglutide 2.4 mg and a mean HbA1c reduction of 1.6%
Lipids and CV risk: Benefits in established CVD (SELECT) are robust
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