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Under normal, unstressed conditions, Nrf2 (Nuclear factor erythroid 2-related factor 2), a critical transcription factor, is bound in the cell's cytoplasm to a repressor sensor protein called Keap1 (Kelch-like ECH-associated protein 1)
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(Left) In liver cells, GLP-1 can mediate cholesterol efflux by acting directly on LXR, or by inducing an increase in ATP-binding cassette transporter A1 (ABCA1) mRNA through Ca2+/calmodulin (CaM)-dependent protein kinase kinase/CAM-dependent protein kinase IV/Prolactin regulatory element binding (CaMKK/CaMKIV/PREB), increasing apolipoprotein AI (apo AI) mRNA and promoter expression, and increasing apo AI secretion, thereby mediating intracellular cholesterol efflux
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