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Cagrilintide, the second generation (2020s) Novo Nordisk took the Pramlintide concept and applied the same half-life extension strategy that they used with Semaglutide: Kept the proline substitutions (anti-amyloid) Added a C20 fatty diacid via a -Glu linker to a lysine residue, albumin binding Additionally stabilized the N- and C-terminal positions Result: Cagrilintide with a half-life of 6.6 days (vs 50 minutes for Pramlintide)
Nanotechnology offers several distinct advantages in improving the efficacy and safety of therapeutic drugs for prostate diseases
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in vitro biological matrices for ADCs stability in WuXi AppTec DMPK Conclusion With the development and the accumulation of experience of antibody-drug conjugates, linker has been regarded as a crucial element in the ADC design
Schucht P, Raineteau O, Schwab OE, Fouad K
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