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D-Retro-Inverso (DRI) modification addresses this by: using D-amino acids (mirror images of natural L-amino acids) and reversing the sequence

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In addition to the total effective dose for a career, short-term limits exist to restrict doses to prevent specific tissue reactions (also known as non-carcinogenic or deterministic effects) to organs, such as skin, lens, blood forming organs and the circulatory and central nervous systems (205)

Orskov C, Poulsen SS, Mller M, Holst JJ

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