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Multiple foci of necrosis (coagulative necrosis) and/or multifocal necrotizing hepatitis can be observed microscopically

Since estrogen helps keep blood vessels flexible, arteries can stiffen when levels drop, resulting in a rise in blood pressure that forces the heart to work harder

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It works by competing with histamine for receptor sites on target cells, blocking histamines effects

Rangasamy T, Misra V, Zhen L, Tankersley CG, Tuder RM, Biswal S: Cigarette smoke-induced emphysema in A/J mice is associated with pulmonary oxidative stress, apoptosis of lung cells, and global alterations in gene expression